First Preliminary Round

BYE

Second Preliminary Round (Round of 32)

Gazelle FC (Chad) / Zamalek 23 Dec 2020 [Gazelle withdrew]  
Zamalek / Gazelle FC (Chad) 6 Jan 2021 [Gazelle withdrew]

First Round (Round of 16) - Group D

Zamalek-0/0-MC Algers "Mouloudia Club d’Alger" (Algeria)  

Date: 12 Feb 2021
Line-Up: Mohamed Abou Gabal / Hazem Emam (Hamid Ahaddad 46") / Mahmoud Alaa / Mahmoud Hamdi "El-Wensh" / Abdullah Gomaa (Ahmed Aboul Fotouh 79") / Ahmed Sayed "Zizo" / Youssef Ibrahim "Obama" / Ferjani Sassi / Tarek Hamed / Emam Ashour (Achraf Bencharki 67") / Marwan Hamdi (Mahmoud Abdel Razek "Shikabala" 46")

Tuengueth FC (Senegal)-0/0-Zamalek  

Date: 23 Feb 2021
Line-Up: Mahmoud Abdel Rehim "Gennesh" / Hamza Mathlouthi / Mahmoud Alaa / Mohamed Abdel Ghani / Ahmed Aboul Fotouh (Abdullah Gomaa 64") / Ahmed Sayed "Zizo" (Hossam Ashraf 71") / Youssef Ibrahim "Obama" / Ferjani Sassi / Tarek Hamed / Achraf Bencharki (Emam Ashour 71") / Osama Faisal (Marwan Hamdi 71")

Espérance "Taragy" (Tunisia)-3/1-Zamalek  

Date: 6 Mar 2021
Zamalek Scorer: Ahmed Aboul Fotouh 40"
Line-Up: Mahmoud Abdel Rehim "Gennesh" / Hamza Mathlouthi (Abdullah Gomaa 60") / Mahmoud Hamdi "El-Wensh" / Mohamed Abdel Ghani / Ahmed Aboul Fotouh 40"   57" / Ahmed Sayed "Zizo" / Youssef Ibrahim "Obama" / Ferjani Sassi / Tarek Hamed / Achraf Bencharki (Osama Faisal 88") / Hamid Ahaddad (Emam Ashour 72")

Zamalek-0/1-Espérance "Taragy" (Tunisia)  

Date: 16 Mar 2021
Line-Up: Mahmoud Abdel Rehim "Gennesh" / Ahmed Eid (Mahmoud Abdel Razek "Shikabala" 68") / Mahmoud Hamdi "El-Wensh" / Mahmoud Alaa / Abdullah Gomaa / Ahmed Sayed "Zizo" / Youssef Ibrahim "Obama" / Ferjani Sassi / Tarek Hamed / Achraf Bencharki / Osama Faisal (Emam Ashour 46")

MC Algers "Mouloudia Club d’Alger" (Algeria)-0/2-Zamalek  

Date: 3 Apr 2021
Zamalek Scorers: Youssef Ibrahim "Obama" 6" / Mahmoud Abdel Razek "Shikabala" 33"
Line-Up: Mahmoud Abdel Rehim "Gennesh" / Hazem Emam / Mahmoud Alaa / Mahmoud Hamdi "El-Wensh" / Ahmed Aboul Fotouh / Mahmoud Abdel Razek "Shikabala" (Abdullah Gomaa 60") / Youssef Ibrahim "Obama" / Ferjani Sassi / Tarek Hamed / Achraf Bencharki / Marwan Hamdi (Hamid Ahaddad 46")

Zamalek-4/1-Tuengueth FC (Senegal)  

Date: 10 Apr 2021
Zamalek Scorers: Mahmoud Hamdi "El-Wensh" 16", 41" / Marwan Hamdi 25", 38"
Line-Up: Mahmoud Abdel Rehim "Gennesh" / Hazem Emam (Hamza Mathlouthi 56") / Mahmoud Alaa / Mahmoud Hamdi "El-Wensh" / Ahmed Aboul Fotouh (Mohamed Abdel Shafi 85") / Mahmoud Abdel Razek "Shikabala" (Ahmed Sayed "Zizo" 70") / Youssef Ibrahim "Obama" / Ferjani Sassi / Tarek Hamed (Islam Gaber 85") / Achraf Bencharki / Marwan Hamdi (Hamid Ahaddad 56")